Oxidative stress in diabetes: implications for vascular and other complications

Dario Pitocco, Carmine Cardillo, Manfredi Tesauro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

191 Citazioni (Scopus)

Abstract

In recent decades, oxidative stress has become a focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence shows that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure. Based on these studies, an emerging concept is that oxidative stress is the "final common pathway" through which the risk factors for several diseases exert their deleterious effects. Oxidative stress causes a complex dysregulation of cell metabolism and cell-cell homeostasis; in particular, oxidative stress plays a key role in the pathogenesis of insulin resistance and β-cell dysfunction. These are the two most relevant mechanisms in the pathophysiology of type 2 diabetes and its vascular complications, the leading cause of death in diabetic patients.
Lingua originaleEnglish
pagine (da-a)21525-21550
Numero di pagine26
RivistaInternational Journal of Molecular Sciences
Volume14
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • diabetes
  • oxidative stress

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