Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Me De Leo; Silvia Borrello; M Passantino; B Palazzotti; Alvaro Mordente; Antonio Daniele; V Filippini; Tommaso Galeotti; Carlo Masullo

Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Me De Leo, Silvia Borrello, M Passantino, B Palazzotti, Alvaro Mordente, Antonio Daniele, V Filippini, Tommaso Galeotti, Carlo Masullo

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

97 Citazioni (Scopus)

Abstract

Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

Lingua originale	English
pagine (da-a)	173-176
Numero di pagine	4
Rivista	Neuroscience Letters
Stato di pubblicazione	Pubblicato - 1998

Keywords

SUPEROSSIDE DISMUTASE
oxidative stress

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title = "Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.",

abstract = "Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.",

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T1 - Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

AU - De Leo, Me

AU - Borrello, Silvia

AU - Passantino, M

AU - Palazzotti, B

AU - Mordente, Alvaro

AU - Daniele, Antonio

AU - Filippini, V

AU - Galeotti, Tommaso

AU - Masullo, Carlo

PY - 1998

Y1 - 1998

N2 - Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

AB - Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

KW - SUPEROSSIDE DISMUTASE

KW - oxidative stress

KW - SUPEROSSIDE DISMUTASE

KW - oxidative stress

UR - http://hdl.handle.net/10807/9301

M3 - Article

SN - 0304-3940

SP - 173

EP - 176

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Abstract

Keywords

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