Oxidative stress and bronchopulmonary dysplasia: Evidences from microbiomics, metabolomics, and proteomics

Giovanni Vento, Federica Iavarone, Chiara Tirone, Letizia Capasso, Cristina Loddo, Francesco Raimondi, Carlo Dani, Vassilios Fanos

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Bronchopulmonary dysplasia is a major issue affecting morbidity and mortality of surviving premature babies. Preterm newborns are particularly susceptible to oxidative stress and infants with bronchopulmonary dysplasia have a typical oxidation pattern in the early stages of this disease, suggesting the important role of oxidative stress in its pathogenesis. Bronchopulmonary dysplasia is a complex disease where knowledge advances as new investigative tools become available. The explosion of the "omics" disciplines has recently affected BPD research. This review focuses on the new evidence coming from microbiomics, metabolomics and proteomics in relation to oxidative stress and pathogenesis of bronchopulmonary dysplasia. Since the pathogenesis is not yet completely understood, information gained in this regard would be important for planning an efficacious prevention and treatment strategy for the future.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaFrontiers in Pediatrics
Volume7
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Bronchopulmonary dysplasia
  • Metabolomics
  • Microbiomics
  • Newborn
  • Oxidative stress
  • Preterm
  • Proteomics

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