Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis

Damiana Pieragostino, Piero Del Boccio, Maria Di Ioia, Luisa Pieroni, Viviana Greco, Giovanna De Luca, Simona D'Aguanno, Claudia Rossi, Diego Franciotta, Diego Centonze, Paolo Sacchetta, Carmine Di Ilio, Alessandra Lugaresi, Andrea Urbani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)


Transthyretin (TTR) is a homotetrameric protein of the CNS that plays a role of as the major thyroxine (T4) carrier from blood to cerebrospinal fluid (CSF). T4 physiologically helps oligodendrocyte precursor cells to turn into myelinating oligodendrocytes, enhancing remyelination after myelin sheet damage. We investigated post-translational oxidative modifications of serum and CSF TTR in multiple sclerosis subjects, highlighting high levels of S-sulfhydration and S-sulfonation of cysteine in position ten only in the cerebral TTR, which correlate with an anomalous TTR protein folding as well as with disease duration. Moreover, we found low levels of free T4 in CSF of multiple sclerosis patients, suggestive of a potential role of these modifications in T4 transport into the brain.
Lingua originaleEnglish
pagine (da-a)1002-1009
Numero di pagine8
Stato di pubblicazionePubblicato - 2013


  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Oxidation-Reduction
  • Prealbumin
  • Protein Isoforms
  • Protein Processing, Post-Translational
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Thyroxine


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