TY - JOUR
T1 - Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology
AU - Improta, Giuseppina
AU - Pettinato, Angela
AU - Høgdall, Estrid
AU - Santeusanio, Giuseppe
AU - Vatrano, Simona
AU - Fraggetta, Filippo
AU - Zannoni, Gian Franco
PY - 2018
Y1 - 2018
N2 - Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.
AB - Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.
KW - 2734
KW - Histology
KW - Medical Laboratory Technology
KW - genetic profile
KW - morphology
KW - ovarian clear cell carcinoma
KW - ovary
KW - 2734
KW - Histology
KW - Medical Laboratory Technology
KW - genetic profile
KW - morphology
KW - ovarian clear cell carcinoma
KW - ovary
UR - http://hdl.handle.net/10807/120175
UR - http://www.appliedimmunohist.com
U2 - 10.1097/PAI.0000000000000662
DO - 10.1097/PAI.0000000000000662
M3 - Article
SN - 1541-2016
SP - N/A-N/A
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
ER -