Ovarian cancer management in the oldest old: Improving outcomes and tailoring treatments

Roberto Bernabei, Giovanni Scambia, Lucia Tortorella, Giuseppe Vizzielli, Domenico Fusco, Giuseppe Ferdinando Colloca, William C. Cho

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Ovarian cancer is the most common cause of death from gynecological cancers in developed countries. It is a common disease of older women at or above 63 years upon diagnosis. Thanks to advance in new treatments, mortality from ovarian cancer has declined in developed countries in the last decade. This decline in mortality rate is unevenly distributed across the age-spectrum. While mortality in younger women has decreased 21.7%, for elderly women it has declined only 2.2%. Even if ovarian cancer is clearly a disease of the elderly, older women are underrepresented in clinical trials, and scant evidence exists for the treatment of women older than 80 years. Moreover, older women are frequently undertreated, receive less chemotherapy and less combination of surgery and chemotherapy, despite the fact that this is considered the optimal treatment modality. This may be mainly due to the lack of evidence and physician's confidence in the management of elderly women with ovarian cancer. In this review, we focus on the management of older women with ovarian cancer, considering geriatric features tied to this population.
Lingua originaleEnglish
pagine (da-a)677-684
Numero di pagine8
RivistaAging and Disease
Volume8
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • 2734
  • Cell Biology
  • Elderly
  • Frailty
  • Geriatrics and Gerontology
  • Neurology (clinical)
  • Ovarian cancer

Fingerprint Entra nei temi di ricerca di 'Ovarian cancer management in the oldest old: Improving outcomes and tailoring treatments'. Insieme formano una fingerprint unica.

Cita questo