Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia a study from the acute leukemia working party of the european society for blood and marrow transplantation

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Non-T-cell depleted haploidentical hematopoietic stem cell transplantation (HaploSCT) is being increasingly used in acute lymphoblastic leukemia (ALL) with improving patient outcomes. We have recently reported that outcomes of adult patients (pts) with ALL in complete remission (CR) receiving HaploSCT are comparable to unrelated donor transplants. We now compared HaploSCT and matched sibling donor (MSD) transplants in pts with ALL. Aim: To assess transplantation outcomes of HaploSCT and MSD transplants in pts with ALL in CR. Methods: We retrospectively analyzed adult patients (≥ 18 years) with ALL who underwent their first allogeneic stem cell transplantation (alloSCT) in first or second CR between 2012 and 2018, either from a T cell replete Haplo or MSD donor, and whose data were reported to the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). Multivariate analysis (MVA) adjusting for differences between the groups was performed using the Cox proportional hazards regression model. Propensity score matching was also performed to reduce confounding effects.
Lingua originaleEnglish
pagine (da-a)53-53
Numero di pagine1
RivistaJOURNAL OF HEMATOLOGY AND ONCOLOGY RESEARCH
Stato di pubblicazionePubblicato - 2021

Keywords

  • Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia a study from the acute leukemia working party of the european society for blood and marrow transplantation

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