Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Theodor Uden; Alice Bertaina; Jonas Abrahamsson; Marc Ansari; Adriana Balduzzi; Jean-Pierre Bourquin; Corinne Gerhardt; Marc Bierings; Henrik Hasle; Arjan Lankester; Kirsten Mischke; Andrew S. Moore; Ian Nivison-Smith; Anna Pieczonka; Christina Peters; Petr Sedlacek; Dirk Reinhardt; Jerry Stein; Birgitta Versluys; Jacek Wachowiak; Leen Willems; Martin Zimmermann; Franco Locatelli; Martin G. Sauer

doi:10.1111/bjh.16441

Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Theodor Uden, Alice Bertaina, Jonas Abrahamsson, Marc Ansari, Adriana Balduzzi, Jean-Pierre Bourquin, Corinne Gerhardt, Marc Bierings, Henrik Hasle, Arjan Lankester, Kirsten Mischke, Andrew S. Moore, Ian Nivison-Smith, Anna Pieczonka, Christina Peters, Petr Sedlacek, Dirk Reinhardt, Jerry Stein, Birgitta Versluys, Jacek WachowiakLeen Willems, Martin Zimmermann, Franco Locatelli, Martin G. Sauer

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

Lingua originale	English
pagine (da-a)	745-750
Numero di pagine	6
Rivista	British Journal of Haematology
Volume	189
DOI	https://doi.org/10.1111/bjh.16441
Stato di pubblicazione	Pubblicato - 2020

Keywords

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
second hematopoietic stem cell transplantation
relapse
children

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10.1111/bjh.16441

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Uden, T., Bertaina, A., Abrahamsson, J., Ansari, M., Balduzzi, A., Bourquin, J.-P., Gerhardt, C., Bierings, M., Hasle, H., Lankester, A., Mischke, K., Moore, A. S., Nivison-Smith, I., Pieczonka, A., Peters, C., Sedlacek, P., Reinhardt, D., Stein, J., Versluys, B., ... Sauer, M. G. (2020). Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children. British Journal of Haematology, 189, 745-750. https://doi.org/10.1111/bjh.16441

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title = "Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children",

abstract = "Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.",

keywords = "acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation, second hematopoietic stem cell transplantation, relapse, children, acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation, second hematopoietic stem cell transplantation, relapse, children",

author = "Theodor Uden and Alice Bertaina and Jonas Abrahamsson and Marc Ansari and Adriana Balduzzi and Jean-Pierre Bourquin and Corinne Gerhardt and Marc Bierings and Henrik Hasle and Arjan Lankester and Kirsten Mischke and Moore, {Andrew S.} and Ian Nivison-Smith and Anna Pieczonka and Christina Peters and Petr Sedlacek and Dirk Reinhardt and Jerry Stein and Birgitta Versluys and Jacek Wachowiak and Leen Willems and Martin Zimmermann and Franco Locatelli and Sauer, {Martin G.}",

year = "2020",

doi = "10.1111/bjh.16441",

language = "English",

volume = "189",

pages = "745--750",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: [email protected], INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",

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Uden, T, Bertaina, A, Abrahamsson, J, Ansari, M, Balduzzi, A, Bourquin, J-P, Gerhardt, C, Bierings, M, Hasle, H, Lankester, A, Mischke, K, Moore, AS, Nivison-Smith, I, Pieczonka, A, Peters, C, Sedlacek, P, Reinhardt, D, Stein, J, Versluys, B, Wachowiak, J, Willems, L, Zimmermann, M, Locatelli, F & Sauer, MG 2020, 'Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children', British Journal of Haematology, vol. 189, pagg. 745-750. https://doi.org/10.1111/bjh.16441

TY - JOUR

T1 - Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

AU - Uden, Theodor

AU - Bertaina, Alice

AU - Abrahamsson, Jonas

AU - Ansari, Marc

AU - Balduzzi, Adriana

AU - Bourquin, Jean-Pierre

AU - Gerhardt, Corinne

AU - Bierings, Marc

AU - Hasle, Henrik

AU - Lankester, Arjan

AU - Mischke, Kirsten

AU - Moore, Andrew S.

AU - Nivison-Smith, Ian

AU - Pieczonka, Anna

AU - Peters, Christina

AU - Sedlacek, Petr

AU - Reinhardt, Dirk

AU - Stein, Jerry

AU - Versluys, Birgitta

AU - Wachowiak, Jacek

AU - Willems, Leen

AU - Zimmermann, Martin

AU - Locatelli, Franco

AU - Sauer, Martin G.

PY - 2020

Y1 - 2020

N2 - Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

AB - Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

KW - acute myeloid leukemia

KW - allogeneic hematopoietic stem cell transplantation

KW - second hematopoietic stem cell transplantation

KW - relapse

KW - children

KW - acute myeloid leukemia

KW - allogeneic hematopoietic stem cell transplantation

KW - second hematopoietic stem cell transplantation

KW - relapse

KW - children

UR - http://hdl.handle.net/10807/228626

U2 - 10.1111/bjh.16441

DO - 10.1111/bjh.16441

M3 - Article

SN - 0007-1048

VL - 189

SP - 745

EP - 750

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Abstract

Keywords

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