Osteosarcopenic obesity: a triple threat for older adults?

Advancing age is associated with body composition changes that impact the health status and overall wellbeing of older adults. Muscle mass decreases, contributing to the loss of strength and physical function, a condition known as sarcopenia. Declining bone mineral density leads to osteopenia or osteoporosis, with an increased risk of fractures. Adipose tissue accumulates, redistributes, and infiltrates organs, causing chronic inflammation, metabolic disturbances, and additional mechanical load on the musculoskeletal system. These pathological conditions are interdependent and result in a range of clinical phenotypes.