Origin of celiac disease: How old are predisposing haplotypes?

Giovanni Battista Gasbarrini, Giuseppe Marangi, Antonio Gasbarrini, Lucrezia Laterza, Franco Scaldaferri, O Rickards, C Martínez Labarga, E Pacciani, F Chilleri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

We recently presented the case of a first century AD young woman, found in the archaeological site of Cosa, showing clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease (CD). However, whether these findings were actually associated to CD was not shown based on genetic parameters. To investigate her human leukocyte antigen (HLA) class II polymorphism, we extracted DNA from a bone sample and a tooth and genotyped HLA using three HLA-tagging single nucleotide polymorphisms for DQ8, DQ2.2 and DQ2.5, specifically associated to CD. She displayed HLA DQ 2.5, the haplotype associated to the highest risk of CD. This is the first report showing the presence of a HLA haplotype compatible for CD in archaeological specimens.
Lingua originaleEnglish
pagine (da-a)5300-5304
Numero di pagine5
RivistaWorld Journal of Gastroenterology
Volume18
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • ancient DNA
  • celiac disease

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