Orienting of spatial attention in Huntington's Disease

M Couette, A Bachoud Levi, P Brugieres, E Sieroff, Paolo Bartolomeo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

25 Citazioni (Scopus)


To explore the functioning of spatial attention in Huntington's Disease (HD), 14 HD patients and 14 age-matched controls performed a cued response time (RT) task with peripheral cues. In Experiment 1, cues were not informative about the future target location, thus eliciting a purely exogenous orienting of attention. At short stimulus-onset asynchrony (SOA), controls showed an initial facilitation for cued locations, later replaced by a cost (inhibition of return, IOR). Patients had a larger and more persistent validity effect, with delayed IOR, resulting from a larger cost for uncued targets. This suggests an impairment of attentional disengaging from cued locations. In Experiment 2, 80% of the cues were valid, thus inducing an initially exogenous, and later endogenous, attentional shift towards the cued box. The validity effect was larger in patients than in controls, again as a result of a disproportionate cost for uncued targets. In Experiment 3, 80% of the cues were invalid, thus inviting participants to endogenously re-orient attention towards the uncued box. Patients could take advantage of invalid cues to re-orient their attention towards the uncued targets but at a longer SOA than controls, thus suggesting that endogenous orienting is preserved in HD, but slowed down by the disengage deficit. The disengage deficit correlated with several radiological and biological markers of HD, thus suggesting a causal relationship between HD and attentional impairments. Cued RT tasks are promising tools for the clinical monitoring of HD and of its potential treatments.
Lingua originaleEnglish
pagine (da-a)1391-1400
Numero di pagine10
Stato di pubblicazionePubblicato - 2008
Pubblicato esternamente


  • Adult
  • Attention
  • Cerebral Cortex
  • Cues
  • Eye Movements
  • Female
  • Humans
  • Huntington Disease
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Orientation
  • Photic Stimulation
  • Psychiatric Status Rating Scales
  • Psychomotor Performance
  • Reaction Time
  • Space Perception


Entra nei temi di ricerca di 'Orienting of spatial attention in Huntington's Disease'. Insieme formano una fingerprint unica.

Cita questo