Oral Specific Desensitization in Food-Allergic Children

Giampiero Patriarca, Eleonora Nucera, Emanuela Pollastrini, Chiara Roncallo, Tiziana Maria Angela De Pasquale, Carla Lombardo, Claudio Pedone, Giovanni Battista Gasbarrini, Alessandro Buonomo, Domenico Schiavino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

114 Citazioni (Scopus)


The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food allergy (on the basis of clinical history, skin prick tests, measurement of specific IgE, and double-blind, placebo-controlled food challenge) underwent a sublingual-oral desensitizing treatment according to new standardized protocols. The control group consisted of 10 patients who followed an elimination diet. The treatment was successfully completed by 85.7% of the patients. Specific IgE showed a significant decrease, while specific IgG(4) showed a significant increase, in all treated patients. The immunological modifications observed in our patients lead us to hypothesize that oral tolerance may be mediated by the same mechanisms as those involved in traditional desensitizing treatments for respiratory and insect sting allergy.
Lingua originaleEnglish
pagine (da-a)1662-1672
Numero di pagine11
RivistaDigestive Diseases and Sciences
Stato di pubblicazionePubblicato - 2007


  • IgE
  • IgG(4)
  • desensitization
  • food allergy


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