TY - JOUR
T1 - Oral Specific Desensitization in Food-Allergic Children
AU - Patriarca, Giampiero
AU - Nucera, Eleonora
AU - Pollastrini, Emanuela
AU - Roncallo, Chiara
AU - De Pasquale, Tiziana Maria Angela
AU - Lombardo, Carla
AU - Pedone, Claudio
AU - Gasbarrini, Giovanni Battista
AU - Buonomo, Alessandro
AU - Schiavino, Domenico
PY - 2007
Y1 - 2007
N2 - The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food allergy (on the basis of clinical history, skin prick tests, measurement of specific IgE, and double-blind, placebo-controlled food challenge) underwent a sublingual-oral desensitizing treatment according to new standardized protocols. The control group consisted of 10 patients who followed an elimination diet. The treatment was successfully completed by 85.7% of the patients. Specific IgE showed a significant decrease, while specific IgG(4) showed a significant increase, in all treated patients. The immunological modifications observed in our patients lead us to hypothesize that oral tolerance may be mediated by the same mechanisms as those involved in traditional desensitizing treatments for respiratory and insect sting allergy.
AB - The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food allergy (on the basis of clinical history, skin prick tests, measurement of specific IgE, and double-blind, placebo-controlled food challenge) underwent a sublingual-oral desensitizing treatment according to new standardized protocols. The control group consisted of 10 patients who followed an elimination diet. The treatment was successfully completed by 85.7% of the patients. Specific IgE showed a significant decrease, while specific IgG(4) showed a significant increase, in all treated patients. The immunological modifications observed in our patients lead us to hypothesize that oral tolerance may be mediated by the same mechanisms as those involved in traditional desensitizing treatments for respiratory and insect sting allergy.
KW - IgE
KW - IgG(4)
KW - desensitization
KW - food allergy
KW - IgE
KW - IgG(4)
KW - desensitization
KW - food allergy
UR - http://hdl.handle.net/10807/25587
M3 - Article
SN - 0163-2116
SP - 1662
EP - 1672
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
ER -