Oral microbiota in human health and disease: A perspective

Luigi Santacroce, Pier Carmine Passarelli, Domenico Azzolino, Lucrezia Bottalico, Ioannis Alexandros Charitos, Angela Pia Cazzolla, Marica Colella, Skender Topi, Franklin Garcia Godoy, Antonio D'Addona

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The evolution of medical knowledge about oral microbiota has increased awareness of its important role for the entire human body health. A wide range of microbial species colonizing the oral cavity interact both with each other and with their host through complex pathways. Usually, these interactions lead to a harmonious coexistence (i.e. eubiosis). However, several factors – including diet, poor oral hygiene, tobacco smoking, and certain medications, among others – can disrupt this weak homeostatic balance (i.e. dysbiosis) with potential implications on both oral (i.e. development of caries and periodontal disease) and systemic health. This article is thus aimed at providing an overview on the importance of oral microbiota in mediating several physiological and pathological conditions affecting human health. In this context, strategies based on oral hygiene and diet as well as the role of probiotics supplementation are discussed.
Lingua originaleEnglish
pagine (da-a)1288-1301
Numero di pagine14
RivistaExperimental Biology and Medicine
Volume248
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • Human microbiota
  • dental caries
  • diet
  • microbiome
  • probiotics
  • oral dysbiosis
  • oral health
  • periodontitis
  • oral biofilm

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