Abstract
Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 ng nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
Lingua originale | English |
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pagine (da-a) | 251-254 |
Numero di pagine | 4 |
Rivista | International Archives of Allergy and Immunology |
Volume | 107 |
Stato di pubblicazione | Pubblicato - 1995 |
Keywords
- Administration, Oral
- Adolescent
- Adult
- Combined Modality Therapy
- Desensitization, Immunologic
- Diet
- Drug Eruptions
- Female
- Humans
- Male
- Middle Aged
- Nickel
- Patch Tests
- Treatment Outcome