TY - JOUR
T1 - Oral contraceptives, human papillomavirus and cervical cancer
AU - La Vecchia, Carlo
AU - Boccia, Stefania
PY - 2014
Y1 - 2014
N2 - Oncogenic human papillomavirus is the key determinant of cervical cancer, but other risk factors interact with it to define individual risk. Among these, there is oral contraceptive (OC) use. A quantitative review of the link between OCs and cervical cancer was performed. Long-term (>5 year) current or recent OC use has been related to an about two-fold excess risk of cervical cancer. Such an excess risk, however, levels off after stopping use, and approaches unity 10 or more years after stopping. The public health implications of OC use for cervical cancer are limited. In any case, such implications are greater in middle-income and low-income countries, as well as in central and eastern Europe and Latin America, where cervical cancer screening and control remain inadequate.
AB - Oncogenic human papillomavirus is the key determinant of cervical cancer, but other risk factors interact with it to define individual risk. Among these, there is oral contraceptive (OC) use. A quantitative review of the link between OCs and cervical cancer was performed. Long-term (>5 year) current or recent OC use has been related to an about two-fold excess risk of cervical cancer. Such an excess risk, however, levels off after stopping use, and approaches unity 10 or more years after stopping. The public health implications of OC use for cervical cancer are limited. In any case, such implications are greater in middle-income and low-income countries, as well as in central and eastern Europe and Latin America, where cervical cancer screening and control remain inadequate.
KW - Gynecological Cancer
KW - Oral contraceptives
KW - cervical cancer
KW - human papillomavirus
KW - Gynecological Cancer
KW - Oral contraceptives
KW - cervical cancer
KW - human papillomavirus
UR - http://hdl.handle.net/10807/64020
U2 - 10.1097/CEJ.0000000000000000
DO - 10.1097/CEJ.0000000000000000
M3 - Article
SN - 0959-8278
VL - 23
SP - 110
EP - 112
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
ER -