Optical detection of infiltration during peripheral intravenous infusion in neonates

Vito D'Andrea*, Giorgia Prontera, Riccardo Carlino, Helena Di Trani, Ilaria Carlettini, Mauro Pittiruti, Giovanni Vento

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: Infiltration and extravasation are common complications during peripheral intravenous infusion in the neonatal intensive care unit, and diagnosis is usually clinical, by inspection and palpation. Delay in diagnosis due to poor surveillance or misinterpretation of clinical signs may carry serious damage to the tissues of the neonate. Recently, a novel technology based on optical detection of infiltration has become available. Methods: We have studied two groups of term and preterm infants receiving non-vesicant intravenous infusions by the peripheral route (24G short peripheral cannulas), and we evaluated the incidence of infiltration. In the first group, we have compared the clinical detection of infiltration versus the detection obtained by a novel optical device, blinding the alarms of the device. In the second group, the comparison was carried out without blinding the alarms. Results: Of the neonates included in this study, 60% were female, 86% had a gestational age <37 weeks (34 & PLUSMN; 2.5 weeks) and a mean birth weight of 2.08 & PLUSMN; 0.4 g. Total recorded monitoring time was 1318 h and average monitoring time for each short peripheral cannula was 26.4 h. The incidence of infiltration was 80%, most of them having a Millam score <2. The novel device showed an overall sensitivity of 88.9% in detecting infiltration. Specificity was 84.4%, as evaluated assuming as standard the clinical diagnosis. Interestingly, in cases of documented infiltration, the event was diagnosed by the optical device approximately 6 h before the clinical diagnosis. Conclusions: Continuous monitoring of the insertion site, as automatically ensured by this novel optical device, may play a complementary role in early detection of infiltration, even if the percentage of false positives and false negatives suggests that periodic clinical assessment by expert nurses cannot be omitted.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Vascular Access
Stato di pubblicazionePubblicato - 2023


  • Short peripheral cannula
  • extravasation
  • intensive care
  • techniques and procedures
  • neonates
  • new devices
  • near infrared light


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