Background: Hypopharynx is the site with the worst prognosis among head and neck SCCs. The aim of the present study was to evaluate the oncological outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different therapeutic modalities. Methods: The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal were reviewed. The correlations of oncological endpoints with tumor parameters and primary treatment were evaluated. Results: The OS rate was 76%, and the DSS rate was 80% at 3 years in the entire group. Sex and T and N classification significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and RT, and the temporal sequence of the two modalities did not affect prognosis. Conclusions: The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in uni- and multivariate analyses for any stage considered. This article is protected by copyright. All rights reserved.
- hypopharyngeal squamous cell carcinoma
- multidisciplinary approach
- primary treatment