Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence.

Karsten Weylandt, Simona Serini, Yong Chen, Hui Min Su, Kyu Lim, Achille Cittadini, Gabriella Calviello*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolopeer review

54 Citazioni (SciVal)

Abstract

lmost forty years ago, it was first hypothesized that an increased dietary\r\nintake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert\r\nprotective effects against several pathologies. Decades of intense preclinical\r\ninvestigation have supported this hypothesis in a variety of model systems.\r\nSeveral clinical cardiovascular studies demonstrated the beneficial health\r\neffects of omega-3 PUFA, leading medical institutions worldwide to publish\r\nrecommendations for their increased intake. However, particularly in recent\r\nyears, contradictory results have been obtained in human studies focusing on\r\ncardiovascular disease and the clinical evidence in other diseases, particularly \r\nchronic inflammatory and neoplastic diseases, was never established to a degree\r\nthat led to clear approval of treatment with omega-3 PUFA. Recent data not in\r\nline with the previous findings have sparked a debate on the health efficacy of\r\nomega-3 PUFA and the usefulness of increasing their intake for the prevention of \r\na number of pathologies. In this review, we aim to examine the controversies on\r\nthe possible use of these fatty acids as preventive/curative tools against the\r\ndevelopment of cardiovascular, metabolic, and inflammatory diseases, as well as\r\nseveral kinds of cancer.
Lingua originaleInglese
pagine (da-a)143109-N/A
RivistaBioMed Research International
Volume2015
Numero di pubblicazione2015
DOI
Stato di pubblicazionePubblicato - 2015

All Science Journal Classification (ASJC) codes

  • Biochimica, Genetica, Biologia Molecolare Generali
  • Immunologia e Microbiologia Generali

Keywords

  • beneficial effects
  • chronic diseases
  • clinical studies
  • epidemiological studies
  • omega-3 PUFA

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