Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence.

Karsten H. Weylandt, Simona Serini, Yong Q. Chen, Hui-Min Su, Kyu Lim, Achille Renato Maria Cittadini, Gabriella Calviello

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

54 Citazioni (SciVal)


lmost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several clinical cardiovascular studies demonstrated the beneficial health effects of omega-3 PUFA, leading medical institutions worldwide to publish recommendations for their increased intake. However, particularly in recent years, contradictory results have been obtained in human studies focusing on cardiovascular disease and the clinical evidence in other diseases, particularly chronic inflammatory and neoplastic diseases, was never established to a degree that led to clear approval of treatment with omega-3 PUFA. Recent data not in line with the previous findings have sparked a debate on the health efficacy of omega-3 PUFA and the usefulness of increasing their intake for the prevention of a number of pathologies. In this review, we aim to examine the controversies on the possible use of these fatty acids as preventive/curative tools against the development of cardiovascular, metabolic, and inflammatory diseases, as well as several kinds of cancer.
Lingua originaleEnglish
pagine (da-a)143109-N/A
RivistaBioMed Research International
Stato di pubblicazionePubblicato - 2015


  • beneficial effects
  • chronic diseases
  • clinical studies
  • epidemiological studies
  • omega-3 PUFA


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