Olfactory perception rehabilitation after total laryngectomy (OPRAT): proposal of a new protocol based on training of sensory perception skills

Ylenia Longobardi, Claudio Parrilla, Giovanni Di Cintio, Eugenio De Corso, Maria Elisabetta Marenda, Giorgia Mari, Gaetano Paludetti, Lucia D'Alatri*, Giulio Cesare Passali

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


PURPOSE: We aim to propose a new protocol for olfaction rehabilitation after total laryngectomy based on training of sensory perception levels using the Nasal Airflow-Inducing Maneuver. METHODS: This is a randomized clinical trial including patients undergoing total laryngectomy between March 2010 and March 2019. Patients with nasal or oral abnormalities, prior olfaction impairment, a muco-ciliary transport time higher than 30 min, positive history for feeding, and neurological disorders were excluded. Thirty-three patients were enrolled and were randomized into two groups: an Experimental group, submitted to the new protocol (olfactory perception rehabilitation after total laryngectomy-OPRAT) and a Control group that did not receive any treatment. Subjective Olfactometry, Chemosensory Complaints Score, and University of Washington Quality of Life version 4 questionnaires were used to assess the outcomes before and after treatment, and at 3-month, 6-month, and 10-month follow-up. RESULTS: Among the 33 patients included (32 men and 1 woman; mean age, 67.94 ± 5.64 years), 17 were subjected to olfaction rehabilitation and 16 did not receive any treatment. At baseline evaluation, there were not significant differences between the two groups. At the end of treatment, the rehabilitated group improved their olfaction capability significantly. Such improvement remained stable over time, and after 10 months, only the Experimental group had significant improvements in all outcome measures. CONCLUSIONS: The OPRAT may guarantee excellent results in the short- and long-term time with positive effects on the Quality of Life.
Lingua originaleEnglish
pagine (da-a)2095-2105
Numero di pagine11
Stato di pubblicazionePubblicato - 2020


  • Head and neck surgery
  • Olfaction
  • Quality of life
  • Rehabilitation
  • Rhinology
  • Total laryngectomy


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