Old measures and new scores in spinal muscular atrophy patients

Elena Stacy Mazzone, Jacqueline Montes, Marion Main, Anna Mayhew, Danielle Ramsey, Allan M. Glanzman, Sally Dunaway, Rachel Salazar, Amy Pasternak, Janet Quigley, Marika Pane, Maria Carmela Pera, Mariacristina Scoto, Sonia Messina, Maria Sframeli, Adele D'Amico, Marleen Van Den Hauwe, Serena Sivo, Nathalie Goemans, Basil T. DarrasPetra Kaufmann, Enrico Silvio Bertini, Darryl C. De Vivo, Francesco Muntoni, Richard Finkel, Eugenio Maria Mercuri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Introduction: A recent Rasch analysis performed on the Hammersmith Functional Motor ScaleExpanded (HFMSE) in patients with spinal muscular atrophy (SMA) identified issues impacting scale validity, redundant items, and disordered thresholds on some items. Methods: We modified the HMFSE scoring based on the Rasch analysis and on expert consensus to establish whether the traditional scoring overestimated the number of patients with changes within 2 points from baseline. Data were collected retrospectively from multicenter data sets in 255 type 2 and 3 SMA patients. Results: The mean 12-month changes using the new and the traditional scoring system did not differ significantly (P>0.05). The numbers of patients who improved or decreased by >2 points were also similar. Conclusions: The presence of outliers using the traditional scoring system was not due to overestimation of changes in activities that were tested bilaterally or to discrepancies in the scoring hierarchy of individual items. Muscle Nerve 52:435-437, 2015
Lingua originaleEnglish
pagine (da-a)435-437
Numero di pagine3
RivistaMUSCLE & NERVE
Volume52
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscular Atrophy, Spinal
  • Psychometrics
  • Rasch analysis
  • Retrospective Studies
  • Severity of Illness Index
  • Spinal Muscular Atrophies of Childhood
  • Young Adult
  • neuromuscular
  • outcome measures
  • scoring
  • spinal muscular atrophy

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