Oct-angiography findings in patients with amblyopia: Comparison between healthy controls, treatment-responsive, and treatment-unresponsive amblyopic patients

Gustavo Savino, Stanislao Rizzo, Annabella Salerni, Gloria Gambini, Chiara Fedeli, Leonardo Paris, Emanuele Crincoli, Maria Cristina Savastano, Daniela Bacherini, Clara Rizzo, Raphael Killian

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

There is no consensus on whether amblyopia affects the retinal vascular plexus and morphology. Previous studies focused on the differences between amblyopic patients and normal controls without evaluating amblyopic eyes after patching. To evaluate differences in the superficial vascular density of amblyopic eyes, normal eyes, and amblyopic eyes reaching normal BCVA after patch therapy, OCTA was used. All patients underwent a comprehensive ophthalmological examination, including visual acuity, refraction, ocular motility tests, and anterior and posterior segment examination. OCTA was performed by an expert physician using the Zeiss Cirrus 5000-HD-OCT Angioplex (Carl Zeiss, Meditec, Inc., Dublin, OH, USA). OCTA scans were performed using a 3 × 3 mm2 and 6 × 6 mm2 fovea-centered image setting. The mean outer macular vessel density in the previously amblyopic group was 19.15 ± 0.51%. This was statistically significantly higher than in both the amblyopic group (18.70 ± 1.14%) and the normal controls (18.18 ± 1.40%) (p = 0.014). The previously amblyopic group also significantly differed from both normal controls and amblyopic eyes with regards to the inner (p = 0.011), outer (p = 0.006), and full (p = 0.003) macular perfusion. Finally, linear regression analysis revealed that BCVA was linearly correlated to outer perfusion in amblyopic (p = 0.003) and ex amblyopic eyes (p < 0.001). Considering the cross-sectional nature of our study, from our results, we can only hypothesize a possible correlation between light stimulation and retinal vasculature development. However, further longitudinal studies are needed to support this hypothesis.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaDiagnostics
Volume11
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Amblyopia
  • Innovative biotechnology
  • Retina
  • Pediatric ophthalmology
  • Personalized medicine
  • Optical coherence tomography angiography

Fingerprint

Entra nei temi di ricerca di 'Oct-angiography findings in patients with amblyopia: Comparison between healthy controls, treatment-responsive, and treatment-unresponsive amblyopic patients'. Insieme formano una fingerprint unica.

Cita questo