TY - JOUR
T1 - Occupational chemical exposure and diabetes mellitus risk
AU - Leso, Veruscka
AU - Capitanelli, Ilaria
AU - Lops, Erika Alessandra
AU - Ricciardi, Walter
AU - Iavicoli, Ivo
PY - 2016
Y1 - 2016
N2 - Diabetes mellitus (DM) is a group of metabolic diseases that may originate from an interaction between genetic and lifestyle risk factors. However, the possible role of occupational chemical exposures in the disease development and progression remains unclear. Therefore, this review aimed to provide a comprehensive evaluation of the relationship between occupational exposure to specific chemical substances or industrial activities and DM morbidity and mortality outcomes. Although some positive findings may support the diabetogenic role of certain pesticides and dioxins in different workplaces, the variable conditions of exposure, the lack of quantitative environmental or biological monitoring data and the different outcomes evaluated do not allow defining a specific exposure-disease causality. Therefore, further epidemiological studies will be necessary to adequately assess modes of action for different substances, dose-response relationships as well as individual susceptibility factors potentially affecting the exposure-disease continuum. Overall, this appears important to adequately assess, communicate and manage risks in occupational chemical exposure settings with the aim to protect workers and build healthier job conditions for diabetic employees.
AB - Diabetes mellitus (DM) is a group of metabolic diseases that may originate from an interaction between genetic and lifestyle risk factors. However, the possible role of occupational chemical exposures in the disease development and progression remains unclear. Therefore, this review aimed to provide a comprehensive evaluation of the relationship between occupational exposure to specific chemical substances or industrial activities and DM morbidity and mortality outcomes. Although some positive findings may support the diabetogenic role of certain pesticides and dioxins in different workplaces, the variable conditions of exposure, the lack of quantitative environmental or biological monitoring data and the different outcomes evaluated do not allow defining a specific exposure-disease causality. Therefore, further epidemiological studies will be necessary to adequately assess modes of action for different substances, dose-response relationships as well as individual susceptibility factors potentially affecting the exposure-disease continuum. Overall, this appears important to adequately assess, communicate and manage risks in occupational chemical exposure settings with the aim to protect workers and build healthier job conditions for diabetic employees.
KW - Diabetes mellitus
KW - chemical exposure
KW - glucose homeostasis
KW - industrial activities
KW - risk assessment and management
KW - Diabetes mellitus
KW - chemical exposure
KW - glucose homeostasis
KW - industrial activities
KW - risk assessment and management
UR - http://hdl.handle.net/10807/93681
U2 - 10.1177/0748233715624594
DO - 10.1177/0748233715624594
M3 - Article
SN - 0748-2337
SP - 1
EP - 28
JO - Toxicology and Industrial Health
JF - Toxicology and Industrial Health
ER -