Obstructive sleep apnea and heart disease: the biomarkers point of view.

Nicola Vitulano, Alessandro Di Marco Berardino, Antonina Re, Graziano Riccioni, Francesco Perna, Flaminio Mormile, Salvatore Valente, Fulvio Bellocci

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)


Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder. Important risk factors for this disease are represented by obesity, male gender, smoking, some endocrinological disturbances, alcohol intake, use of benzodiazepines, and craniofacial alterations. It is well known that OSAS is a frequent comorbidity as well as a relevant risk factor for cardiovascular diseases (CVD), especially in patients with hypertension, coronary artery disease (CAD), arrhythmias, and heart failure. Furthermore, therapy with continuous positive airway pressure devices (CPAP) has been shown to significantly reduce the incidence of serious cardiovascular consequences. Interactions between OSAS and the cardiovascular system (CVS) can eventually result mainly in coronary atherosclerosis. These two conditions are connected by a complex biomarkers network. An extensive overview of these pathways could be helpful to better understand the causes of cardiovascular impairment in patients with OSAS.
Lingua originaleEnglish
pagine (da-a)588-599
Numero di pagine12
RivistaFrontiers in Bioscience
Stato di pubblicazionePubblicato - 2013


  • apnee ostruttive nel sonno
  • biomarkers
  • heart disease
  • malattie cardiache
  • obstructive sleep apnea


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