Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine

Elisa Gremese, Gianfranco Ferraccioli, Antonio Carletto, Melissa Padovan, Fabiola Atzeni, Bernd Raffeiner, Anna Rita Giardina, Ennio Giulio Favalli, Gian Luca Erre, Roberto Gorla, Mauro Galeazzi, Rosario Foti, Fabrizio Cantini, Carlo Salvarani, Ignazio Olivieri, Giovanni Lapadula

Risultato della ricerca: Contributo in rivistaArticolo in rivista

128 Citazioni (Scopus)

Abstract

Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti-tumor necrosis factor α (anti-TNFα) therapy for progressive and active disease despite treatment with methotrexate or other disease-modifying antirheumatic drugs.
Lingua originaleEnglish
pagine (da-a)94-100
Numero di pagine7
RivistaARTHRITIS CARE & RESEARCH
Volume65
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Aged
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antirheumatic Agents
  • Arthritis, Rheumatoid
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunoglobulin G
  • Individualized Medicine
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Obesity
  • Receptors, Tumor Necrosis Factor
  • Registries
  • Remission Induction
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha

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