TY - JOUR
T1 - Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
AU - Cintoni, M.
AU - Grassi, F.
AU - Palombaro, M.
AU - Rinninella, Emanuele
AU - Pulcini, G.
AU - Di, Donato A.
AU - Salvatore, Lisa
AU - Quero, Giuseppe
AU - Tortora, Giampaolo
AU - Alfieri, Sergio
AU - Gasbarrini, Antonio
AU - Mele, Maria Cristina
PY - 2023
Y1 - 2023
N2 - Background: Pancreatic cancer incidence is growing, but the prognosis for survival is still poor. Patients with pancreatic cancer often suffer from malnutrition and sarcopenia, two clinical conditions that negatively impact oncological clinical outcomes. The aim of this systematic review was to analyze the impact of different nutritional interventions on clinical outcomes in patients with pancreatic cancer during chemotherapy. Methods: A systematic review of MedLine, EMBASE, and Web of Science was carried out in December 2022, identifying 5704 articles. Titles and abstracts of all records were screened for eligibility based on inclusion criteria, and nine articles were included. Results: All nine articles included were prospective studies, but a meta-analysis could not be performed due to heterogenicity in nutritional intervention. This Systematic Review shows an improvement in Quality of Life, nutritional status, body composition, oral intake, and Karnofsky Performance Status, following nutritional interventions. Conclusions: This Systematic Review in pancreatic cancer patients during chemotherapies does not allow one to draw firm conclusions. However, nutritional support in pancreatic cancer patients is advisable to ameliorate oncological care. Further well-designed prospective studies are needed to identify nutritional support’s real impact and to establish a reliable way to improve nutritional status of pancreatic cancer patients during chemotherapy.
AB - Background: Pancreatic cancer incidence is growing, but the prognosis for survival is still poor. Patients with pancreatic cancer often suffer from malnutrition and sarcopenia, two clinical conditions that negatively impact oncological clinical outcomes. The aim of this systematic review was to analyze the impact of different nutritional interventions on clinical outcomes in patients with pancreatic cancer during chemotherapy. Methods: A systematic review of MedLine, EMBASE, and Web of Science was carried out in December 2022, identifying 5704 articles. Titles and abstracts of all records were screened for eligibility based on inclusion criteria, and nine articles were included. Results: All nine articles included were prospective studies, but a meta-analysis could not be performed due to heterogenicity in nutritional intervention. This Systematic Review shows an improvement in Quality of Life, nutritional status, body composition, oral intake, and Karnofsky Performance Status, following nutritional interventions. Conclusions: This Systematic Review in pancreatic cancer patients during chemotherapies does not allow one to draw firm conclusions. However, nutritional support in pancreatic cancer patients is advisable to ameliorate oncological care. Further well-designed prospective studies are needed to identify nutritional support’s real impact and to establish a reliable way to improve nutritional status of pancreatic cancer patients during chemotherapy.
KW - Oral Nutritional Supplements
KW - Quality of Life
KW - body composition
KW - nutritional support
KW - pancreatic cancer
KW - supportive care
KW - Oral Nutritional Supplements
KW - Quality of Life
KW - body composition
KW - nutritional support
KW - pancreatic cancer
KW - supportive care
UR - https://publicatt.unicatt.it/handle/10807/231999
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85147692195&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147692195&origin=inward
U2 - 10.3390/nu15030727
DO - 10.3390/nu15030727
M3 - Article
SN - 2072-6643
VL - 15
SP - 727-N/A
JO - Nutrients
JF - Nutrients
IS - 3
ER -
