TY - JOUR
T1 - Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts
AU - Ballarin, Francesco
AU - Faggiano, Elena
AU - Manzoni, Andrea
AU - Quarteroni, Alfio
AU - Rozza, Gianluigi
AU - Ippolito, Sonia
AU - Antona, Carlo
AU - Scrofani, Roberto
PY - 2017
Y1 - 2017
N2 - A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier–Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parameterization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases.
AB - A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier–Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parameterization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases.
KW - Cardiovascular simulations
KW - Computational reduction strategies
KW - Computer Simulation
KW - Coronary Artery Bypass
KW - Coronary Artery Disease
KW - Coronary Vessels
KW - Coronary bypass grafts
KW - Data assimilation
KW - Geometrical parameterization
KW - Hemodynamics
KW - Humans
KW - Models, Cardiovascular
KW - Patient-specific computing
KW - Cardiovascular simulations
KW - Computational reduction strategies
KW - Computer Simulation
KW - Coronary Artery Bypass
KW - Coronary Artery Disease
KW - Coronary Vessels
KW - Coronary bypass grafts
KW - Data assimilation
KW - Geometrical parameterization
KW - Hemodynamics
KW - Humans
KW - Models, Cardiovascular
KW - Patient-specific computing
UR - http://hdl.handle.net/10807/174166
U2 - 10.1007/s10237-017-0893-7
DO - 10.1007/s10237-017-0893-7
M3 - Article
SN - 1617-7959
VL - 16
SP - 1373
EP - 1399
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
ER -