Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice

A. Borghetti; A. Giacomelli; V. Borghi; A. Ciccullo; A. Dusina; M. Fabbiani; S. Rusconi; M. Zazzi; C. Mussini; Simona Di Giambenedetto

doi:10.1093/ofid/ofab103

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice

A. Borghetti
, A. Giacomelli
, V. Borghi
, A. Ciccullo
, A. Dusina
, M. Fabbiani
, S. Rusconi
, M. Zazzi
, C. Mussini
, Simona Di Giambenedetto

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VFs). In this dataset from clinical practice investigating the impact of past nucleoside reverse-transcriptase inhibitor resistance on this strategy, the combination of M184V/I plus at least 1 thymidine analog-associated mutation significantly increased the risk of VF.

Lingua originale	Inglese
pagine (da-a)	ofab103-ofab103
Rivista	Open Forum Infectious Diseases
Volume	8
Numero di pubblicazione	7
DOI	https://doi.org/10.1093/ofid/ofab103
Stato di pubblicazione	Pubblicato - 2021

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Oncologia
Malattie Infettive

Keywords

HIV
dolutegravir
lamivudine
maintenance therapy
resistance-associated mutations

Accesso al documento

10.1093/ofid/ofab103

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Borghetti, A., Giacomelli, A., Borghi, V., Ciccullo, A., Dusina, A., Fabbiani, M., Rusconi, S., Zazzi, M., Mussini, C., & Di Giambenedetto, S. (2021). Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice. Open Forum Infectious Diseases, 8(7), ofab103-ofab103. https://doi.org/10.1093/ofid/ofab103

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title = "Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice",

abstract = "The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VFs). In this dataset from clinical practice investigating the impact of past nucleoside reverse-transcriptase inhibitor resistance on this strategy, the combination of M184V/I plus at least 1 thymidine analog-associated mutation significantly increased the risk of VF.",

keywords = "HIV, dolutegravir, lamivudine, maintenance therapy, resistance-associated mutations, HIV, dolutegravir, lamivudine, maintenance therapy, resistance-associated mutations",

author = "A. Borghetti and A. Giacomelli and V. Borghi and A. Ciccullo and A. Dusina and M. Fabbiani and S. Rusconi and M. Zazzi and C. Mussini and \{Di Giambenedetto\}, Simona",

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doi = "10.1093/ofid/ofab103",

language = "English",

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Borghetti, A, Giacomelli, A, Borghi, V, Ciccullo, A, Dusina, A, Fabbiani, M, Rusconi, S, Zazzi, M, Mussini, C & Di Giambenedetto, S 2021, 'Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice', Open Forum Infectious Diseases, vol. 8, n. 7, pagg. ofab103-ofab103. https://doi.org/10.1093/ofid/ofab103

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice. / Borghetti, A.; Giacomelli, A.; Borghi, V. et al.
In: Open Forum Infectious Diseases, Vol. 8, N. 7, 2021, pag. ofab103-ofab103.

Risultato della ricerca: Contributo in rivista › Articolo

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AU - Borghetti, A.

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AU - Borghi, V.

AU - Ciccullo, A.

AU - Dusina, A.

AU - Fabbiani, M.

AU - Rusconi, S.

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AU - Mussini, C.

AU - Di Giambenedetto, Simona

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AB - The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VFs). In this dataset from clinical practice investigating the impact of past nucleoside reverse-transcriptase inhibitor resistance on this strategy, the combination of M184V/I plus at least 1 thymidine analog-associated mutation significantly increased the risk of VF.

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KW - dolutegravir

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KW - maintenance therapy

KW - resistance-associated mutations

KW - HIV

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KW - maintenance therapy

KW - resistance-associated mutations

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Borghetti A, Giacomelli A, Borghi V, Ciccullo A, Dusina A, Fabbiani M et al. Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice. Open Forum Infectious Diseases. 2021;8(7):ofab103-ofab103. doi: 10.1093/ofid/ofab103