TY - JOUR
T1 - Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis
AU - Montuschi, Paolo
AU - Paris, D
AU - Montella, S
AU - Melck, D
AU - Mirra, V
AU - Santini, G
AU - Mores, Nadia
AU - Montemitro, E
AU - Majo, F
AU - Lucidi, V
AU - Bush, A
AU - Motta, A
AU - Santamaria, F.
PY - 2014
Y1 - 2014
N2 - The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.
AB - The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.
KW - Cystic fibrosis
KW - Exhaled breath condensate
KW - Metabolomics
KW - NMR spectroscopy
KW - Personalised medicine
KW - Primary ciliary dyskinesia
KW - Cystic fibrosis
KW - Exhaled breath condensate
KW - Metabolomics
KW - NMR spectroscopy
KW - Personalised medicine
KW - Primary ciliary dyskinesia
UR - https://publicatt.unicatt.it/handle/10807/60948
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84906930142&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84906930142&origin=inward
U2 - 10.1164/rccm.201402-0249LE
DO - 10.1164/rccm.201402-0249LE
M3 - Article
SN - 1073-449X
VL - 190
SP - 229
EP - 233
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - Luglio
ER -