Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis

Paolo Montuschi, Nadia Mores, Debor Paris, Silvi Montella, Dominiqu Melck, Giusepp Santini, Enz Montemitro, Fabi Majo, Vincenzin Lucidi, Andre Bush, Andre Motta, Francesc Santamaria

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

35 Citazioni (Scopus)

Abstract

The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.
Lingua originaleEnglish
pagine (da-a)229-233
Numero di pagine5
RivistaAmerican Journal of Respiratory and Critical Care Medicine
Volume190
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Cystic fibrosis
  • Exhaled breath condensate
  • Metabolomics
  • NMR spectroscopy
  • Personalised medicine
  • Primary ciliary dyskinesia

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