Abstract
The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.
Lingua originale | English |
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pagine (da-a) | 229-233 |
Numero di pagine | 5 |
Rivista | American Journal of Respiratory and Critical Care Medicine |
Volume | 190 |
DOI | |
Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- Cystic fibrosis
- Exhaled breath condensate
- Metabolomics
- NMR spectroscopy
- Personalised medicine
- Primary ciliary dyskinesia