Novel Drugs Targeting Microtubules: the Role of Epothilones

Maria Gabriella Ferrandina, Giovanni Scambia, Marisa Mariani, Mirko Andreoli, Cristiano Ferlini, S Shahabi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

Among the drugs targeting microtubule functions by interfering with tubulin subunits, epothilones represent a class of anticancer agents which recently entered clinical development. Although epothilones share mechanisms of action similar to taxanes, they have non-overlapping mechanisms of resistance; in particular, while overexpression of class III β-tubulin plays a major role in taxane resistance, epothilones display their highest efficacy in class III β-tubulin overexpressing malignancies. Three compounds belonging to this family (patupilone, ixabepilone and sagopilone), have been actively investigated in clinical trials, and some of them are at an advanced stage of development. This review provides a comprehensive analysis of the available literature on epothilones, focusing on their clinical development and potential as an additional weapon in the arsenal against tumors.
Lingua originaleEnglish
pagine (da-a)2793-2803
Numero di pagine11
RivistaCURRENT PHARMACEUTICAL DESIGN
Volume18
Stato di pubblicazionePubblicato - 2012

Keywords

  • Epothilones

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