Not only gustatory sweating and flushing: Signs and symptoms associated to the Frey syndrome and the role of botulinum toxin A therapy

Emanuele Scarano, Giovanni Almadori, Jacopo Galli, Maria Raffaella Marchese, Francesco Bussu, Stefano Settimi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: The classic symptoms of Frey syndrome are gustatory sweating and flushing. Aims of the study were to describe prevalenceand severity of typical and atypical presentations of the disorder and to assess the effects of botulinum neurotoxin A (BoNT-A) therapy in patients with Frey syndrome after parotidectomy. Methods: In this prospective, observational study on 18 patients, we assessed symptom severity before therapy, after 15 days, 1, 3 and 6 months' follow-up with the sweating-flushing-itch-paresthesia-pain (SFIPP) Frey scale specifically designed by the authors themselves for this study. Results: Before BoNT-A injection, all patients (100%) complained gustatory sweating, 80% paresthesia, 77% gustatory flushing, 60% pain and 60% gustatory itch. The SFIPP-Frey overall score and the symptom-specific ones decreased significantly at each post-therapy control. Conclusions: The prevalence of “unusual” manifestations is not negligible. BoNT-A improves symptoms severity. The SFIPP-Frey scale may be useful to assess symptoms and to monitor post-therapy outcomes.
Lingua originaleEnglish
pagine (da-a)949-955
Numero di pagine7
RivistaHEAD & NECK
Volume43
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Frey syndrome
  • auriculotemporal syndrome
  • botulinum toxin A
  • gustatory sweating
  • onabotulinum toxin A
  • parotidectomy

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