TY - JOUR
T1 - Normothermia does not improve postoperative hemostasis nor does it reduce inflammatory activation in patients undergoing primary isolated coronary artery bypass
AU - Gaudino, Mario Fulvio Luigi
AU - Zamparelli, Roberto
AU - Andreotti, Felicita
AU - Burzotta, Francesco
AU - Iacoviello, Licia
AU - Glieca, Franco
AU - Benedett, Maria
AU - Benedetti, Marta
AU - Maseri, Attilio
AU - Schiavello, Rocco
AU - Possati, Gianfederico
PY - 2002
Y1 - 2002
N2 - Background: Despite its common acceptance in clinical practice, the effective benefits of normothermic systemic perfusion during coronary artery bypass operations are far from established. Methods: A total of 113 patients undergoing primary isolated coronary artery bypass were randomly assigned to normothermic (37°C) or hypothermic (26°C) systemic perfusion. The clinical course of the patients was prospectively recorded, and several inflammatory and fibrinolytic markers (C-reactive protein, fibrinogen, interleukin 6, plasminogen activator inhibitor 1, prothrombin time, activated partial thromboplastin time, platelets, and white blood cell counts) were determined before surgical intervention; 24, 48, and 72 hours thereafter; and at hospital discharge. Results: Postoperatively, 2 in-hospital deaths occurred in the normothermic series and none in the hypothermic series. Four patients had a myocardial infarction, 1 had respiratory insufficiency, 1 had to be reoperated on for graft malfunction, and none had renal insufficiency in the hypothermic group versus 1 patient with each of these complications in the normothermic series. Mean blood loss in the first 24 hours was 766 ± 223 mL in the normothermic group and 740 ± 220 mL in the hypothermic group. None of these differences was statistically significant. Similarly, no significant difference in the postoperative level of any of the measured variables at any time point was evident between the patients in the normothermic and hypothermic groups. Conclusion: Normothermic systemic perfusion does not influence the clinical course or the extent of inflammatory and hemostatic activation in patients undergoing primary isolated coronary artery bypass.
AB - Background: Despite its common acceptance in clinical practice, the effective benefits of normothermic systemic perfusion during coronary artery bypass operations are far from established. Methods: A total of 113 patients undergoing primary isolated coronary artery bypass were randomly assigned to normothermic (37°C) or hypothermic (26°C) systemic perfusion. The clinical course of the patients was prospectively recorded, and several inflammatory and fibrinolytic markers (C-reactive protein, fibrinogen, interleukin 6, plasminogen activator inhibitor 1, prothrombin time, activated partial thromboplastin time, platelets, and white blood cell counts) were determined before surgical intervention; 24, 48, and 72 hours thereafter; and at hospital discharge. Results: Postoperatively, 2 in-hospital deaths occurred in the normothermic series and none in the hypothermic series. Four patients had a myocardial infarction, 1 had respiratory insufficiency, 1 had to be reoperated on for graft malfunction, and none had renal insufficiency in the hypothermic group versus 1 patient with each of these complications in the normothermic series. Mean blood loss in the first 24 hours was 766 ± 223 mL in the normothermic group and 740 ± 220 mL in the hypothermic group. None of these differences was statistically significant. Similarly, no significant difference in the postoperative level of any of the measured variables at any time point was evident between the patients in the normothermic and hypothermic groups. Conclusion: Normothermic systemic perfusion does not influence the clinical course or the extent of inflammatory and hemostatic activation in patients undergoing primary isolated coronary artery bypass.
KW - C-Reactive Protein
KW - Cardiopulmonary Bypass
KW - Coronary Artery Bypass
KW - Female
KW - Hemostasis, Surgical
KW - Humans
KW - Hypothermia, Induced
KW - Interleukin-6
KW - Male
KW - Plasminogen Activator Inhibitor 1
KW - Postoperative Period
KW - Prospective Studies
KW - C-Reactive Protein
KW - Cardiopulmonary Bypass
KW - Coronary Artery Bypass
KW - Female
KW - Hemostasis, Surgical
KW - Humans
KW - Hypothermia, Induced
KW - Interleukin-6
KW - Male
KW - Plasminogen Activator Inhibitor 1
KW - Postoperative Period
KW - Prospective Studies
UR - http://hdl.handle.net/10807/157839
U2 - 10.1067/mtc.2002.120709
DO - 10.1067/mtc.2002.120709
M3 - Article
SN - 0022-5223
VL - 123
SP - 1092
EP - 1100
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
ER -