Normalisation of high CA 19-9 values in autoimmune hepatitis after steroidal treatment.

Massimo Montalto, Riccardo Ricci, Giovanni Battista Gasbarrini, Luca Santoro, Monica Vastola, Valentina Curigliano, Fabio Maria Vecchio, Raffaele Manna

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)

Abstract

Carbohydrate 19-9 antigen (CA 19-9) is considered a specific marker of pancreatobiliary adenocarcinomas, but slight increase of its levels can be found in several non-malignant diseases of the liver, such as autoimmune hepatitis. We describe a case of marked CA 19-9 elevation (up to 898.0 U/ml) in a patient with autoimmune hepatitis. Laboratory and instrumental examinations excluded malignant diseases. Immunohistochemical analysis for CA 19-9 and MIB-1, performed on liver biopsy, showed reactivity in inflammatory areas, in particular in bile ductule cells and hepatocytes in ductular metaplasia, suggesting that these cells could be involved in CA 19-9 serum levels increase. After steroids, the clinical picture improved and all the laboratory parameters normalised.
Lingua originaleEnglish
pagine (da-a)603-608
Numero di pagine6
RivistaInternational Journal of Immunopathology and Pharmacology
Stato di pubblicazionePubblicato - 2005

Keywords

  • autoimmune hepatitis
  • ca 19.9
  • steroidal therapy

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