NON-NATURAL SEMAPHORINS 3 AND THEIR MEDICAL USE

Luca Tamagnone (Inventor), Serini Guido (Inventor), Giraudo Enrico (Inventor)

Risultato della ricerca: BrevettoPatent

Abstract

The present invention relates to non-naturally occurring, mutated Semaphorin 3 molecules. Particularly, the invention relates to the mutated Semaphorin 3 or the functional fragment thereof that exhibit improved properties and pharmacologic effects, e.g., in the treatment of angiogenic disease and cancer. In addition, the present invention relates to nucleic acid molecules encoding such polypeptides, and vectors and hosts comprising such nucleic acids. The invention further relates to methods for producing the polypeptides of the invention, and to methods of using them in the treatment of disease, in particular in the medical intervention of angiogenic diseases, tumors and/or cancer.
Lingua originaleEnglish
Numero di brevettoWO/2016/135130
Stato di pubblicazionePubblicato - 21 giu 2016

Keywords

  • Angiogenesis
  • Cancer
  • Endothelial cells
  • Plexins
  • Semaphorins

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