TY - JOUR
T1 - Non-invasive three-dimensional electro-anatomical imaging of the site of origin of outflow tract ventricular arrhythmias with magnetocardiographic mapping
AU - Lombardi, G
AU - Sorbo, Anna Rita
AU - Guida, Maria Grazia
AU - La Brocca, L
AU - Fenici, Riccardo
AU - Brisinda, Donatella
PY - 2017
Y1 - 2017
N2 - Ventricular arrhythmias (VAs) with left bundle-branch-block and inferior axis morphology (LBBB-IA), suggestive of
outflow tract (OT) origin, are a challenge in sports medicine because they can be benign or expression of a silent
cardiomyopathy. Non-invasive classification is essential to plan ablation strategy if required. We aimed to evaluating
magnetocardiographic (MCG) discrimination of OT-VAs site of origin (SoO). MCG and ECG data of 26 sports activity
practitioners, with OT-VAs were analyzed. OT-VAs-SoO was classified with discriminant analysis (DA) of 8 MCG
parameters and with invasively-validated ECG algorithms. MCG inverse source-localization merged with magnetic
resonance (CMR) provided three-dimensional electro-anatomical imaging (MCG 3D-EAI). ECG classification was
univocal in 73%. MCG-DA differentiated right ventricular OT from aortic sinus cusp VAs, with 94.7% accuracy. MCG
3D-EAI confirmed OT-VAs-SoO in CMR images. In cases undergoing ablation, MCG 3D-EAI was confirmed by
CARTO 3D-EAI. MCG-DA improves non-invasive classification of OT-VAs-SoO. Further comparison with
interventional results is required.
AB - Ventricular arrhythmias (VAs) with left bundle-branch-block and inferior axis morphology (LBBB-IA), suggestive of
outflow tract (OT) origin, are a challenge in sports medicine because they can be benign or expression of a silent
cardiomyopathy. Non-invasive classification is essential to plan ablation strategy if required. We aimed to evaluating
magnetocardiographic (MCG) discrimination of OT-VAs site of origin (SoO). MCG and ECG data of 26 sports activity
practitioners, with OT-VAs were analyzed. OT-VAs-SoO was classified with discriminant analysis (DA) of 8 MCG
parameters and with invasively-validated ECG algorithms. MCG inverse source-localization merged with magnetic
resonance (CMR) provided three-dimensional electro-anatomical imaging (MCG 3D-EAI). ECG classification was
univocal in 73%. MCG-DA differentiated right ventricular OT from aortic sinus cusp VAs, with 94.7% accuracy. MCG
3D-EAI confirmed OT-VAs-SoO in CMR images. In cases undergoing ablation, MCG 3D-EAI was confirmed by
CARTO 3D-EAI. MCG-DA improves non-invasive classification of OT-VAs-SoO. Further comparison with
interventional results is required.
KW - magnetocardiographic mapping
KW - outflow tract ventricular arrhythmias
KW - magnetocardiographic mapping
KW - outflow tract ventricular arrhythmias
UR - http://hdl.handle.net/10807/212272
U2 - 10.1093/eurheartj/ehx501.P793
DO - 10.1093/eurheartj/ehx501.P793
M3 - Meeting Abstract
VL - 2017
SP - N/A-N/A
JO - ICMJE
JF - ICMJE
ER -