Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women

C. Tersigni, Nicoletta Di Simone, E. Tempestilli, F. Cianfrini, R. Russo, M. C. Moruzzi, I. D. Amar, A. Fiorelli, Giovanni Scambia, Paola Villa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


In post-menopausal period vulvo-vaginal atrophy (VVA)-related symptoms may seriously affect women's quality of life. Hormonal replacement therapy effectively relieves these symptoms but it is not always safe or accepted, and a non-hormonal treatment is often needed instead. Over a period of 12 weeks, we tested the effect of a twice-a-week vulvo-vaginal application of a hyaluronic acid, AC collagen, isoflavones and vitamins-based cream (Perilei Pausa(®)) on 35 women in post-menopausal period, reporting VVA-related symptoms. After 12 weeks of treatment with Perilei Pausa(®) a significant improvement in vaginal dryness, vulvo-vaginal itching, dyspareunia (P < 0.001), dysuria (P = 0.02), nocturia (P = 0.009) and pollakiuria (P = 0.005) was reported by the women. Colposcopical score assessing the intensity of atrophic colpitis, cervico-vaginal paleness and petechiae was also reduced (P = 0.037, P = 0.016 and P = 0.032, respectively). No significant difference in terms of maturation value of cervico-vaginal epithelium was observed. In conclusion, Perilei Pausa(®) may represent an effective and safe alternative treatment of symptomatic VVA in post-menopausal women.
Lingua originaleEnglish
pagine (da-a)835-838
Numero di pagine4
RivistaJournal of Obstetrics and Gynaecology
Stato di pubblicazionePubblicato - 2015


  • post-menopausal women
  • vulvo-vaginal atrophy


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