Non-fatherhood or mutation? A probabilistic approach to parental exclusion in paternity testing

Vincenzo Lorenzo Pascali, A. P. Dawid, J. Mortera

Risultato della ricerca: Contributo in rivistaArticolo in rivista

66 Citazioni (Scopus)

Abstract

The occurrence of germline mutations at microsatellite loci poses problems in ascertaining non-fatherhood status in paternity testing. We describe the appropriate probabilistic analysis for computing the likelihood ratio in favour of paternity while allowing for mutation, for all 18 relevant combinations of seemingly incompatible parental genotypes. We allow arbitrary and possibly different mutation rates in paternal and maternal germlines. We describe a stationary mutation model for expressing the required allele-specific transition mutation rates in terms of overall mutation rates, and compare the likelihood ratios calculated from this and from other mutation models suggested in the literature. We also show how to derive an upper bound on the likelihood ratio, depending only on the overall mutation rate
Titolo tradotto del contributo[Autom. eng. transl.] Non-fatherhood or mutation? A probabilistic approach to parental exclusion in paternity testing
Lingua originaleItalian
pagine (da-a)55-61
Numero di pagine7
RivistaForensic Science International
Stato di pubblicazionePubblicato - 2001

Keywords

  • Germline mutation
  • Mutation model
  • Paternity test

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