Non-Epileptic Seizures (NES) are predicted by depressive and dissociative symptoms

Giacomo Della Marca, Marianna Mazza, Annalisa Martini, Marta Scoppetta, Catello Vollono, Maria Luigia Vaccario, Salvatore Mazza, Pietro Bria, Maria Azzurra Valenti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

18 Citazioni (Scopus)


OBJECTIVES: (1) To measure depressive and dissociative symptoms in a population of patients with Non-Epileptic Seizures (NES, or pseudo-seizures); (2) To compare NES with Epileptic subjects and Normal controls; (3) To try to define a personality profile specific, or typical, of NES patients. METHODS: Patients: 30 consecutive patients (21 females and 9 males, mean age 32.9+/-11.7 years) with NES diagnosed on clinical basis and confirmed by video-EEG recording; 30 patients with epilepsy matched for age and sex who had presented at least two seizures in the 12 months prior to the study despite pharmacological treatment; 30 Control subjects, healthy volunteers, matched for age and sex. Psychometric evaluation: Hamilton Rating Scale for Depression (HDRS), Dissociative Experience Scale (DES), Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Groups were compared by means of one-way Analysis of Variance (ANOVA) for independent samples, followed by posthoc Tukey HSD Test, with Bonferroni correction for multiple comparisons. RESULTS: Depressive and dissociative symptoms showed a significantly higher prevalence in the NES group as compared to Epileptics (p<0.001) and Controls (p<0.001), whereas patients with epilepsy did not differ from Controls. The analysis of the MMPI-2 in NES group showed a general increase in most MMPI-2 T-scores as compared to Epileptics and Controls, rather than a constant elevation (T-score>70) of one or more scales. No specific personality profile could be identified for the NES group. CONCLUSIONS: Our results are consistent with the hypothesis that depression and dissociative mechanisms are important precursors to the development and expression of NES.
Lingua originaleEnglish
pagine (da-a)91-96
Numero di pagine6
RivistaEpilepsy Research
Stato di pubblicazionePubblicato - 2009


  • Non-Epileptic Seizures
  • depression
  • dissociative symptoms


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