Non-alcoholic fatty liver disease is associated with high prevalence of gastro-oesophageal reflux symptoms

Luca Miele, Giovanni Cammarota, Vittoria Vero, Simona Racco, Consuelo Cefalo, Giuseppe Marrone, Maurizio Pompili, Gian Ludovico Rapaccini, Antonella Bianco, Raffaele Landolfi, Antonio Gasbarrini, Antonio Grieco

Risultato della ricerca: Contributo in rivistaArticolo in rivista


BACKGROUND: Gastro-oesophageal reflux symptoms are usually reported by patients with obesity and metabolic syndrome. Aim of this study was to assess the prevalence and clinical characteristics of gastro-oesophageal reflux symptoms in subjects with non-alcoholic fatty liver disease. METHODS: Cross-sectional, case-control study of 185 consecutive patients with non-alcoholic fatty liver disease and an age- and sex-matched control group of 112 healthy volunteers. Participants were interviewed with the aid of a previously validated questionnaire to assess lifestyle and reflux symptoms in the 3 months preceding enrolment. Odds ratios were determined before and after adjustment for body mass index, increased waist circumference, physical activity, metabolic syndrome and proton pump inhibitors and/or antiacid medication. RESULTS: The prevalence of heartburn and/or regurgitation and of at least one of gastro-oesophageal reflux symptoms was significantly higher in the non-alcoholic fatty liver disease group. Non-alcoholic fatty liver disease subjects were associated to higher prevalence of heartburn (adjusted odds ratios: 2.17, 95% confidence intervals: 1.16-4.04), regurgitation (adjusted odds ratios: 2.61, 95% confidence intervals: 1.24-5.48) and belching (adjusted odds ratios: 2.01, 95% confidence intervals: 1.12-3.59) and had higher prevalence of at least one GER symptom (adjusted odds ratios: 3.34, 95% confidence intervals: 1.76-6.36). CONCLUSION: Non-alcoholic fatty liver disease is associated with a higher prevalence of gastro-oesophageal reflux symptoms.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaDigestive and Liver Disease
Stato di pubblicazionePubblicato - 2012


  • gastro-oesophageal reflux disease
  • non-halcoholic fatty liver disease


Entra nei temi di ricerca di 'Non-alcoholic fatty liver disease is associated with high prevalence of gastro-oesophageal reflux symptoms'. Insieme formano una fingerprint unica.

Cita questo