No-reflow reversibility: a study based on serial assessment of multiple biomarkers

Francesco Burzotta, Carlo Trani, Filippo Crea, Giampaolo Niccoli, Francesco Fracassi, Nicola Cosentino, Antonio Maria Leone, Italo Porto, Anna Severino, Giuseppe De Luca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

No-reflow after primary percutaneous coronary intervention (pPCI) may be reversible. 40 patients undergoing pPCI were evaluated by assessing either improvement or lack of changes regarding angiographic and electrocardiographic indexes of no-reflow between admission and pre-discharge. Myeloperoxidase (MPO; in nanograms per milliliter), C-reactive protein (CRP; in milligrams per liter), endothelin-1 (ET-1; in nanograms per milliliter), angiopoietin-2 (Ang-2, in picograms per milliliter), and their pre-discharge/basal values variations (Δ) were related to no-reflow evolution. ΔMPO and ΔCRP were greater in patients with sustained no-reflow or lack of ST-segment resolution (STR) as compared with those with reversible no-reflow or lack of STR (p = 0.033, p = 0.04, p < 0.001, and p = 0.001, respectively), whereas ΔET-1 was similar in the two groups. ΔAng-2 was greater in patients with sustained no-reflow or lack of STR as compared with those with reversible no-reflow or lack of STR (p = 0.01 and 0.044, respectively). Bigger ΔMPO, ΔCRP (increasing levels), and ΔAng-2 (decreasing levels) are associated with sustained no-reflow, thus they might have a role in no-reflow evolution.
Lingua originaleEnglish
pagine (da-a)798-807
Numero di pagine10
RivistaJournal of Cardiovascular Translational Research
Volume6
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • NO-REFLOW
  • primary percutaneous coronary intervention

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