Abstract
We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.
RESEARCH DESIGN AND METHODS:
Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 microg/day calcitriol or placebo and followed-up for 2 years.
RESULTS:
At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point.
CONCLUSIONS:
At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis.
Lingua originale | English |
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pagine (da-a) | 162-163 |
Numero di pagine | 2 |
Rivista | Diabetes Care |
Stato di pubblicazione | Pubblicato - 2010 |
Keywords
- diabete
- insulina
- vit D