NO points to epigenetics in vascular development

Simona Nanni, Claudia Colussi, B Illi, J Rosati, F Spallotta, A Farsetti, Mc Capogrossi, C. Gaetano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
Lingua originaleEnglish
pagine (da-a)447-456
Numero di pagine10
RivistaCardiovascular Research
Volume90
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Animals
  • Blood Vessels
  • Cell Differentiation
  • Embryonic Stem Cells
  • Epigenesis, Genetic
  • Humans
  • Mesoderm
  • Models, Cardiovascular
  • Models, Genetic
  • Nitric Oxide
  • Signal Transduction

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