NO points to epigenetics in vascular development

B Illi, C Colussi, J Rosati, F Spallotta, Simona Nanni, A Farsetti, Mc Capogrossi, C. Gaetano

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)


Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
Lingua originaleEnglish
pagine (da-a)447-456
Numero di pagine10
RivistaCardiovascular Research
Stato di pubblicazionePubblicato - 2011


  • endothelium
  • nitric oxide


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