The nm23 gene, originally identified by differential hybridization between two murine melanoma cell lines endowed with different metastatic potential, has been reported to play a metastasis suppressor function in different experimentale models. Several studies have focused on the favorable clinical significance of nm23 overexpression as a metastasis suppessor marker in breast, prostate, and gastric cancer, although conflicting data have been reported. In our laboratory, the immunohistochemical expression of nm23-H1 has been Investigated in a series of 106 primary human ovarian carcinomas in order to determine its possible association with clinicopatholoigcla characteristics and epidermal growth factors receptor (EGFR).
|Numero di pagine||4|
|Rivista||Annals of the New York Academy of Sciences|
|Stato di pubblicazione||Pubblicato - 1996|
- nm23,ovarian cancer