NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles

Antonio Buonerba; Rosita Lapenta; Anna Donniacuo; Magda Licasale; Elena Vezzoli; Stefano Milione; Carmine Capacchione; Mario Felice Tecce; Andrea Falqui; Roberto Piacentini; Claudio Grassi; Alfonso Grassi

doi:10.1038/s41598-020-68397-1

NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles

Antonio Buonerba, Rosita Lapenta, Anna Donniacuo, Magda Licasale, Elena Vezzoli, Stefano Milione, Carmine Capacchione, Mario Felice Tecce, Andrea Falqui, Roberto Piacentini, Claudio Grassi, Alfonso Grassi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

1 Citazioni (Scopus)

Abstract

Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect

Lingua originale	English
pagine (da-a)	N/A-N/A
Numero di pagine	14
Rivista	Scientific Reports
Volume	2020
DOI	https://doi.org/10.1038/s41598-020-68397-1
Stato di pubblicazione	Pubblicato - 2020

Keywords

NIR multiphoton ablation
cancer cells

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Buonerba, A., Lapenta, R., Donniacuo, A., Licasale, M., Vezzoli, E., Milione, S., Capacchione, C., Tecce, M. F., Falqui, A., Piacentini, R., Grassi, C., & Grassi, A. (2020). NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles. Scientific Reports, 2020, N/A-N/A. https://doi.org/10.1038/s41598-020-68397-1

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title = "NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles",

abstract = "Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect",

keywords = "NIR multiphoton ablation, cancer cells, NIR multiphoton ablation, cancer cells",

author = "Antonio Buonerba and Rosita Lapenta and Anna Donniacuo and Magda Licasale and Elena Vezzoli and Stefano Milione and Carmine Capacchione and Tecce, {Mario Felice} and Andrea Falqui and Roberto Piacentini and Claudio Grassi and Alfonso Grassi",

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doi = "10.1038/s41598-020-68397-1",

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Buonerba, A, Lapenta, R, Donniacuo, A, Licasale, M, Vezzoli, E, Milione, S, Capacchione, C, Tecce, MF, Falqui, A, Piacentini, R , Grassi, C & Grassi, A 2020, 'NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles', Scientific Reports, vol. 2020, pagg. N/A-N/A. https://doi.org/10.1038/s41598-020-68397-1

TY - JOUR

T1 - NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles

AU - Buonerba, Antonio

AU - Lapenta, Rosita

AU - Donniacuo, Anna

AU - Licasale, Magda

AU - Vezzoli, Elena

AU - Milione, Stefano

AU - Capacchione, Carmine

AU - Tecce, Mario Felice

AU - Falqui, Andrea

AU - Piacentini, Roberto

AU - Grassi, Claudio

AU - Grassi, Alfonso

PY - 2020

Y1 - 2020

N2 - Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect

AB - Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect

KW - NIR multiphoton ablation

KW - cancer cells

KW - NIR multiphoton ablation

KW - cancer cells

UR - http://hdl.handle.net/10807/160986

U2 - 10.1038/s41598-020-68397-1

DO - 10.1038/s41598-020-68397-1

M3 - Article

SN - 2045-2322

VL - 2020

SP - N/A-N/A

JO - Scientific Reports

JF - Scientific Reports

ER -

NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles

Abstract

Keywords

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