New strategies for the management of no-reflow after primary percutaneous coronary intervention

Filippo Crea, Giampaolo Niccoli, Nicola Cosentino, Cristina Spaziani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

The myocardial no-reflow phenomenon is characterized by a reduced antegrade myocardial blood flow despite an open infarct-related artery in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Importantly, no-reflow is known to be associated with unfavorable clinical outcome and prognosis. It is a complex phenomenon and is caused by the variable combination of four pathogenetic components: distal atherothrombotic embolization, ischemic injury, reperfusion injury and susceptibility of coronary microcirculation to injury. As a consequence, appropriate strategies to prevent or treat each of these components are expected to reduce the occurrence of no-reflow. Mechanical and pharmacological approaches performed before, during and after performing myocardial revascularization have been investigated in recent studies, in order to reduce the rate of no-reflow. In this article, we concentrate on the major preventive and therapeutic approaches currently available for the management of the no-reflow phenomenon.
Lingua originaleEnglish
pagine (da-a)615-630
Numero di pagine16
RivistaExpert Review of Cardiovascular Therapy
Volume9
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Animals
  • Coronary Vessels
  • Embolism
  • Endovascular Procedures
  • Heart Catheterization
  • Humans
  • Microcirculation
  • Myocardial Infarction
  • Myocardial Ischemia
  • Myocardial Reperfusion Injury
  • Myocardial Revascularization
  • No-Reflow Phenomenon

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