TY - JOUR
T1 - New olfactometric findings in Parkinson's disease
AU - Passali, Giulio Cesare
AU - Bove, Francesco
AU - Vargiu, Lucrezia
AU - Bentivoglio, Anna Rita
AU - Anzivino, Roberta
AU - De Corso, Eugenio
AU - Galli, Jacopo
AU - Rigante, Mario
AU - Pandolfini, Manlio
AU - Sergi, Bruno
AU - Giuliani, Monica
AU - Cianfrone, Francesca
AU - Paludetti, Gaetano
AU - Fasano, Alfonso
PY - 2017
Y1 - 2017
N2 - OBJECTIVES:\r\n\r\nTo investigate in Parkinson's disease-affected patients a correlation between hyposmia and gastrointestinal dysfunction and their possible identical etiopathogenesis.\r\nDESIGN:\r\n\r\nRetrospective cohort study.\r\nSETTING:\r\n\r\nENT and neurology departments (Gemelli Hospital, Rome, Italy).\r\nPARTICIPANTS:\r\n\r\nA total of 78 patients with diagnosis of PD according to the UK Brain Bank criteria.\r\nINCLUSION CRITERIA:\r\n\r\ninformed consent and olfactory testing executed; exclusion criteria: signs of dementia according to the DSM-IV criteria; Mini Mental State Examination score ≤26; head trauma; central neurological disorders, nasal or systemic diseases potentially affecting olfactory function. Motor condition was assessed by means of Hoehn and Yahr staging and by section III of the Unified PD Rating Scale, performed off and on medications.\r\nMAIN OUTCOME MEASURES:\r\n\r\nThe patients underwent olfactory evaluation (TDI score), after rhinomanometry with nasal decongestion. A total of 25 non-motor symptoms were evaluated through an interview.\r\nRESULTS:\r\n\r\nOlfactory dysfunction was objectively found in 91.0% of patients, a percentage higher than the subjective hyposmia reported (55.1%) P = 0.0001. Seven patients (9.0%) were normosmic, 49 (62.8%) hyposmic and 22 (28.2%) anosmic. Subjective hyposmia, constipation, bloating and dyspepsia differed across groups, being higher in anosmic and hyposmic ones than in the normosmic group. P value was ≤0.05 for each symptom. Despite the original results, this study has the limitation of being based on subjective ratings by a relatively limited group of patients.\r\nCONCLUSIONS:\r\n\r\nHyposmia and gastrointestinal symptoms are correlated, and this would support a possible common origin; the CNS could be reached through two different pathways, both starting in the peripheral nervous system.
AB - OBJECTIVES:\r\n\r\nTo investigate in Parkinson's disease-affected patients a correlation between hyposmia and gastrointestinal dysfunction and their possible identical etiopathogenesis.\r\nDESIGN:\r\n\r\nRetrospective cohort study.\r\nSETTING:\r\n\r\nENT and neurology departments (Gemelli Hospital, Rome, Italy).\r\nPARTICIPANTS:\r\n\r\nA total of 78 patients with diagnosis of PD according to the UK Brain Bank criteria.\r\nINCLUSION CRITERIA:\r\n\r\ninformed consent and olfactory testing executed; exclusion criteria: signs of dementia according to the DSM-IV criteria; Mini Mental State Examination score ≤26; head trauma; central neurological disorders, nasal or systemic diseases potentially affecting olfactory function. Motor condition was assessed by means of Hoehn and Yahr staging and by section III of the Unified PD Rating Scale, performed off and on medications.\r\nMAIN OUTCOME MEASURES:\r\n\r\nThe patients underwent olfactory evaluation (TDI score), after rhinomanometry with nasal decongestion. A total of 25 non-motor symptoms were evaluated through an interview.\r\nRESULTS:\r\n\r\nOlfactory dysfunction was objectively found in 91.0% of patients, a percentage higher than the subjective hyposmia reported (55.1%) P = 0.0001. Seven patients (9.0%) were normosmic, 49 (62.8%) hyposmic and 22 (28.2%) anosmic. Subjective hyposmia, constipation, bloating and dyspepsia differed across groups, being higher in anosmic and hyposmic ones than in the normosmic group. P value was ≤0.05 for each symptom. Despite the original results, this study has the limitation of being based on subjective ratings by a relatively limited group of patients.\r\nCONCLUSIONS:\r\n\r\nHyposmia and gastrointestinal symptoms are correlated, and this would support a possible common origin; the CNS could be reached through two different pathways, both starting in the peripheral nervous system.
KW - olfactory disorders
KW - parkinson's disease
KW - olfactory disorders
KW - parkinson's disease
UR - https://publicatt.unicatt.it/handle/10807/93450
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85011559378&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011559378&origin=inward
U2 - 10.1111/coa.12816
DO - 10.1111/coa.12816
M3 - Article
SN - 1749-4478
VL - 42
SP - 837
EP - 843
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
IS - 4
ER -