New models for cancer research: Human cancer stem cell xenografts

Marta Baiocchi; Mauro Biffoni; Lucia Ricci-Vitiani; Emanuela Pilozzi; Ruggero De Maria Marchiano

doi:10.1016/j.coph.2010.05.002

New models for cancer research: Human cancer stem cell xenografts

Marta Baiocchi
, Mauro Biffoni
, Lucia Ricci-Vitiani
, Emanuela Pilozzi
, Ruggero De Maria Marchiano

Istituto Superiore di Sanita
Sant'Andrea Hospital

Risultato della ricerca: Contributo in rivista › Articolo

38 Citazioni (Scopus)

Abstract

Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies. Â© 2010 Elsevier Ltd.

Lingua originale	Inglese
pagine (da-a)	380-384
Numero di pagine	5
Rivista	Current Opinion in Pharmacology
Volume	10
DOI	https://doi.org/10.1016/j.coph.2010.05.002
Stato di pubblicazione	Pubblicato - 2010

OSS delle Nazioni Unite

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Keywords

Animals
Antineoplastic Agents
Cell Line, Tumor
Drug Discovery
Drug Discovery3003 Pharmaceutical Science
Humans
Mice
Mice, SCID
Neoplasm Transplantation
Neoplasms, Experimental
Neoplastic Stem Cells
Pharmacology
Xenograft Model Antitumor Assays

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10.1016/j.coph.2010.05.002

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AU - Baiocchi, Marta

AU - Biffoni, Mauro

AU - Ricci-Vitiani, Lucia

AU - Pilozzi, Emanuela

AU - De Maria Marchiano, Ruggero

PY - 2010

Y1 - 2010

N2 - Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies. Â© 2010 Elsevier Ltd.

AB - Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies. Â© 2010 Elsevier Ltd.

KW - Animals

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Drug Discovery

KW - Drug Discovery3003 Pharmaceutical Science

KW - Humans

KW - Mice

KW - Mice, SCID

KW - Neoplasm Transplantation

KW - Neoplasms, Experimental

KW - Neoplastic Stem Cells

KW - Pharmacology

KW - Xenograft Model Antitumor Assays

KW - Animals

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Drug Discovery

KW - Drug Discovery3003 Pharmaceutical Science

KW - Humans

KW - Mice

KW - Mice, SCID

KW - Neoplasm Transplantation

KW - Neoplasms, Experimental

KW - Neoplastic Stem Cells

KW - Pharmacology

KW - Xenograft Model Antitumor Assays

UR - http://hdl.handle.net/10807/112823

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DO - 10.1016/j.coph.2010.05.002

M3 - Article

SN - 1471-4892

VL - 10

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JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

New models for cancer research: Human cancer stem cell xenografts

Abstract

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Keywords

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