New models for cancer research: Human cancer stem cell xenografts

Ruggero De Maria Marchiano, Marta Baiocchi, Mauro Biffoni, Lucia Ricci-Vitiani, Emanuela Pilozzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

38 Citazioni (Scopus)

Abstract

Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies. © 2010 Elsevier Ltd.
Lingua originaleEnglish
pagine (da-a)380-384
Numero di pagine5
RivistaCurrent Opinion in Pharmacology
Volume10
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Animals
  • Antineoplastic Agents
  • Cell Line, Tumor
  • Drug Discovery
  • Drug Discovery3003 Pharmaceutical Science
  • Humans
  • Mice
  • Mice, SCID
  • Neoplasm Transplantation
  • Neoplasms, Experimental
  • Neoplastic Stem Cells
  • Pharmacology
  • Xenograft Model Antitumor Assays

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