Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

7 Citazioni (Scopus)

Abstract

Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Neurotrophin
  • Retinal degeneration

Fingerprint

Entra nei temi di ricerca di 'Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations'. Insieme formano una fingerprint unica.

Cita questo