TY - JOUR
T1 - Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations
AU - Abed, Edoardo
AU - Corbo, Giovanni
AU - Falsini, Benedetto
PY - 2014
Y1 - 2014
N2 - Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
AB - Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
KW - Neurotrophin
KW - Retinal degeneration
KW - Neurotrophin
KW - Retinal degeneration
UR - http://hdl.handle.net/10807/61949
U2 - 10.1007/s40259-014-0110-5
DO - 10.1007/s40259-014-0110-5
M3 - Article
VL - 2014
SP - N/A-N/A
JO - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
ER -