Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations

Edoardo Abed, Giovanni Corbo, Benedetto Falsini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

7 Citazioni (Scopus)


Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
Stato di pubblicazionePubblicato - 2014


  • Neurotrophin
  • Retinal degeneration


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